Iodide Transport: Inhibition by Agents Reacting at the Membrane

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Science  20 Jan 1967:
Vol. 155, Issue 3760, pp. 335-336
DOI: 10.1126/science.155.3760.335


Accumulation of iodide by thyroid tissue is inhibited by two phospholipase A-free proteins from cobra venom, filipin, crude phospholipase C, and lysolecithin. The venom proteins decrease K+ in tissue but do not significantly affect incorporation of phosphorus-32 into phospholipid or stimulation of this process by thyrotropin. However, filipin and crude phospholipase C, like thyrotropin, do increase phospholipid formation.