Passive Transfer of Tuberculin Reactivity in Vitro

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Science  20 Jan 1967:
Vol. 155, Issue 3760, pp. 337-338
DOI: 10.1126/science.155.3760.337


A factor capable of effecting passive transfer in vivo of delayed hypersensitivity to tuberculin to recipients that are tuberculin negative was isolated from the dialyzate of disrupted leukocytes of tuberculin-positive individuals. After this factor was incubated with cultures of peripheral leukocytes from tuberculin-negative individuals, the addition of purified protein derivative of tubercle bacilli resulted in leukocyte stimulation similar to that observed after addition of purified protein derivative to leukocytes from tuberculin-positive individuals.