Depression of Circulating Interferon Response in Balb/c Mice after Urethan Treatment

Science  27 Jan 1967:
Vol. 155, Issue 3761, pp. 482-484
DOI: 10.1126/science.155.3761.482


Urethan, when given to female Balb/c mice, impaired the capacity of these animals to produce circulating interferon. The effect appeared rapidly after a single injection of either 1 or 1.5 milligrams of urethan per gram of body weight and was of short duration. The possibility that this inhibition of the production of interferon plays a role in the enhancement of viral leukemia by urethan should now be considered.

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