Mouse Immunoglobulin Allotypes: Detection with Rabbit Antiserums

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Science  03 Feb 1967:
Vol. 155, Issue 3762, pp. 562-567
DOI: 10.1126/science.155.3762.562


An antiserum with allotypic specificity for mouse γ2a-globulins was prepared in a rabbit by injection of 7S γ2-globulin of C57BL/6 mice. The antibody reacted with an isoantigen in the 7S γ2-globulins of normal serum of mouse strains belonging to the lg-1b allotype class (C57BL/6, C57BL/10, and SJL strains). No precipitin reaction was observed with serum from 18 other inbred mice strains representing other lg-1 allotype classes.