Neoplastic Transformation of Rat Thymic Cells Induced in vitro by Gross Leukemia Virus

See allHide authors and affiliations

Science  03 Feb 1967:
Vol. 155, Issue 3762, pp. 585-587
DOI: 10.1126/science.155.3762.585


Cultures of embryonal rat thymus infected initially with Gross leukemia virus have, at the present time, abundantly replicated infectious virus particles for 20 months. Cells from these cultures, after 3 months in vitro, displayed morphological changes and induced formation of tumors upon isotransplantation. The tumors were serially transplantable, and subsequent transplants continue to carry the initial Gross leukemia virus.