Magnesium Pemoline: Lack of Facilitation in Human Learning, Memory, and Performance Tests

See allHide authors and affiliations

Science  03 Feb 1967:
Vol. 155, Issue 3762, pp. 603-605
DOI: 10.1126/science.155.3762.603


Either a placebo or 25 or 37.5 milligrams of magnesium pemoline was administered on a doubleblind basis to three intelligencematched groups of normal, adult males. Learning and 24-hour retention tests included verbal learning, motor learning, and classical conditioning. Short-term memory tests were administered through both the visual and auditory modalities. Arm-hand steadiness and visual reaction time performance tests were included. The only measures revealing significant group differences showed the performance of subjects given pemoline was inferior to that of subjects given a placebo.