Evolution of Immunoglobulins: Structural Homology of Kappa and Lambda Bence Jones Proteins

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Science  17 Feb 1967:
Vol. 155, Issue 3764, pp. 828-835
DOI: 10.1126/science.155.3764.828


The amino acid sequence of a human lamba chain has been determined. There are many identities in sequence with human kappa chains, but this intraspecies homology is less than the interspecies homology of kappa light chains of man and mouse. Structural relationships suggest a common evolutionary origin and early differentiation of light- and heavy-chain genes.