Synaptic Noise as a Source of Variability in the Interval between Action Potentials

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Science  17 Feb 1967:
Vol. 155, Issue 3764, pp. 842-844
DOI: 10.1126/science.155.3764.842


The source of variability in the interval between action potentials has been identified in a class of cat spinal motoneurons. The observed random fluctuations in membrane potential (synaptic noise) together with an empirical description of spike generation accurately predict the statistical structure of variability observed to occur in the neuron's discharge.