Calcium-Induced Activation of Phosphorylase in Rat Hearts

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Science  03 Mar 1967:
Vol. 155, Issue 3766, pp. 1108-1109
DOI: 10.1126/science.155.3766.1108


Isolated perfused rat hearts exposed to increased calcium concentrations demonstrated a marked activation of phosphorylase, the maximum occurring about 15 seconds after the peak of the positive inotropic response. These observations provide an explanation for the failure of earlier investigations to demonstrate a significant calcium-induced increase in the active form of phosphorylase in the intact heart.