Heme and Globin Synthesis Control: Observations in vivo in Beta Thalassemia

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Science  03 Mar 1967:
Vol. 155, Issue 3766, pp. 1116-1118
DOI: 10.1126/science.155.3766.1116


After administration of glycine-2-14C to a patient with thalassemia, the specific activities of heme and globin of F hemoglobin were consistently higher than those of hemoglobin A. After reaching a maximum, the ratio of the specific activity of heme to that of globin remained constant within each hemoglobin. Explanations considered include dilution by preformed subunits, differential turnover of hemoglobins, and possibly more than one heme-synthesizing pool.