Reports

Crayfish Muscle: Permeability to Sodium Induced by Calcium Depletion

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Science  10 Mar 1967:
Vol. 155, Issue 3767, pp. 1263-1266
DOI: 10.1126/science.155.3767.1263

Abstract

Membrane of crayfish muscle fibers becomes selectively permeable to sodium when the calcium concentration of the bathing medium is reduced. Removal of calcium or its reduction below 1 or 2 millimole per liter causes large transient depolarizations up to 70 millivolts in amplitude. They resemble pro longed action potentials and occur only in the presence of sodium. The responses are abolished when tris(hydroxymethyl)aminomethane or lithium is substituted for sodium, and are blocked by tetrodotoxin even in the presence of sodium.

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