Oxidative Phosphorylation in Experimental Bilirubin Encephalopathy

Science  10 Mar 1967:
Vol. 155, Issue 3767, pp. 1288-1289
DOI: 10.1126/science.155.3767.1288


Mitochondria from the whole brain or cerebellum of newborn guinea pigs with experimental bilirubin encephalopathy failed to exhibit uncoupling of oxidative phosphorylation. The pigment concentrations required to initiate uncoupling in vitro are much higher than those found in the brain of neurotoxic animals.