Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide

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Science  17 Mar 1967:
Vol. 155, Issue 3768, pp. 1417-1419
DOI: 10.1126/science.155.3768.1417


Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.