Circadian Periodicity in Susceptibility to Lidocaine Hydrochloride

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Science  07 Apr 1967:
Vol. 156, Issue 3771, pp. 100-102
DOI: 10.1126/science.156.3771.100


Separate groups of mice standardized in an alternating 12-hour-light,12-hour-dark regimen were treated with lidocaine hydrochloride every 3 hours over a 24-hour period. The results indicate a quantitative circadian periodicity with maximal convulsant activity at 2100 hours which was approximately a fourteen fold increase over the values observed at 1500 hours.