Suppressor Selection for Amino Acid Replacements Expected on the Basis of the Genetic Code

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Science  21 Apr 1967:
Vol. 156, Issue 3773, pp. 394-397
DOI: 10.1126/science.156.3773.394


In studies with A protein mutants of the tryptophan synthetase of Escherichia coli, missense supressors have been used to select for codon changes and corresponding amino acid replacements that are normally unobservable. The technique has permitted the detection of additional amino acid replacements expected on the basis of the genetic code.