Hexokinase Isoenzymes in Human Erythrocytes: Association of Type II with Fetal Hemoglobin

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Science  05 May 1967:
Vol. 156, Issue 3775, pp. 646-648
DOI: 10.1126/science.156.3775.646


Hexokinase activity in human erythrocytes is associated with three electrophoretically distinct bands. Normal adult erythrocytes contain hexokinases Types I and III. Type II hexokinase is present in the erythrocytes of newborn infants and absent from those of normal adults; it is, however, present in erythrocytes of adults with hereditary persistence of fetal hemoglobin. Type II hexokinase and fetal hemtoglobin appear to be associated.