Reports

Quinacrine (Atebrin): Mode of Action

See allHide authors and affiliations

Science  05 May 1967:
Vol. 156, Issue 3775, pp. 655-656
DOI: 10.1126/science.156.3775.655

Abstract

Quinacrine at a concentration of 8 x 10-4 mole per liter is bactericidal for Escherichia coli, blocks DNA synthesis, and inhibits the syntheses of RNA and protein strongly. At a concentration of 2x 10-4 mole per liter, the drug is bacteriostatic, the syntheses of protein and DNA (but not that of RNA) are partially inhibited, and the bacteria grow into giant filaments. Impairment of DNA replication is proposed as the mode of action of quinacrine.