Two Types Of Lambda Polypeptide Chains In Human Immunoglobulins

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Science  19 May 1967:
Vol. 156, Issue 3777, pp. 947-948
DOI: 10.1126/science.156.3777.947


Two antigenic subtypes of human lambda polypeptide chains were distinguished by rabbit antiserum produced to a lambda Bence Jones protein. Lambda Bence Jones proteins and G myeloma proteins with lambda light chains were identified as being in one or the other subtype. The Oz (+) lambda chain subtype is present in light chains from pooled normal human immunoglobulin G and in whole normal immunoglobulin G molecules.