Drug-Induced Tolerance for Skin Allografts across the H-2 Barrier in Adult Mice

See allHide authors and affiliations

Science  19 May 1967:
Vol. 156, Issue 3777, pp. 951-954
DOI: 10.1126/science.156.3777.951


Mice treated with methylhydrazine derivatives for 3 to 4 weeks before the transplantation showed markedly prolonged survival times for allogeneic skin grafts differing at the H-2 histocompatibility locus. Presumably permanent tolerance was induced in about 20 to 30 percent of the mice when the drug treatment was combined with a single injection of additional donor antigen. The tolerance persists without further drug treatment and is specific for donor tissue.