Field Ion Microscopical Imaging of Biomolecules

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Science  19 May 1967:
Vol. 156, Issue 3777, pp. 961-963
DOI: 10.1126/science.156.3777.961


specimen molecules are protected from field desorption by embedding them in a platinum matrix, with the use of electrolytic codeposition on tungsten tips. High-resolution helium ion images are obtaind when the biomolecules are exposed during gradual removal of surface layers by controlled field evaporation. Structured images of individual molecules of coenzyme I and vitamin B12are seen.