Tetrodotoxin Derivatives: Chemical Structure and Blockage of Nerve Membrane Conductance

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Science  19 May 1967:
Vol. 156, Issue 3777, pp. 976-979
DOI: 10.1126/science.156.3777.976


The nerve-impuilse-blocking actions of derivatives of tetrodotoxin have been tested on lobster and squid axons. The block produced by deoxytetrodotoxin was similar to that produced by tetrodotoxin and was probably caused by tetrodotoxin contamination. Tetrodaminotoxin and anhydrotetrodotoxin also produced a similar block but at such high concentrations that tetrodotoxin contamination cannot be ruled out. The hydroxyl group of C4 and the hemilactal oxygen links play an important role for the nerve-blocking action.