Lack of End-Product Inhibition and Repression of Leucine Synthesis in a Strain of Salmonella typhimurium

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Science  26 May 1967:
Vol. 156, Issue 3778, pp. 1107-1109
DOI: 10.1126/science.156.3778.1107


Mutants of Salmonella have been isolated which luck either end product inhibition or repression of leucine biosynthesis. In a minimal saltsglucose medium, growth is not impaired by the lack of either control mechanism alone. The loss of both control mechanisms, however, leads to a 43 percent reduction in cell yield and a 1.5-fold reduction in the growth rate.