Lambda Chains in Cold Agglutinins

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Science  26 May 1967:
Vol. 156, Issue 3778, pp. 1111-1112
DOI: 10.1126/science.156.3778.1111


Type L light chains have been found in the cold agglutinins in the serums of three patients with chronic hemolytic anemia. Altholugh two of these cold agglutinins are unusual in that they do not have specificity to I or i red-cell antigens (one of these has, in addition, cryoglobuilin property), the third is a cold agglutinin of I specificity. Previously reported cold agglutinins from such patients have all been of type K; this is tlhe first report of type L cold agglutinins associated with chronic hemolytic anemia.