Strophanthidin-Sensitive Transport of Cesium and Sodium in Muscle Cells

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Science  02 Jun 1967:
Vol. 156, Issue 3779, pp. 1248-1250
DOI: 10.1126/science.156.3779.1248


Uptake of cesium-134 ions into muscle cells is reduced to very low values by the presence of 10-5M strophanthidin in the Ringer solution. Cesium ions can induce extrusion of sodium from muscle cells in which the intracellular sodium content is elevated. The cesium-induced extra efflux of sodium-22 is inhibited by the external presence of 10-5M strophanthidin. The coupling between inward movement of cesium and outward movement of sodium appears to be chemical in nature. The evidence suggests that cesium ions are transported into muscle cells by a system of sites or carriers that requires a source of metabolic energy for ion turnover to occur.