Renal Erythropoietic Factor: Role of Ions and Vasoactive Agents in Erythropoietin Formation

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Science  09 Jun 1967:
Vol. 156, Issue 3780, pp. 1367-1368
DOI: 10.1126/science.156.3780.1367


Evidence is provided for the existence of a renal erythropoietic factor, devoid of vasopressor activity, which upon interaction in vitro with normal serum yields erythropoietin. When undialyzed serum is used, erythropoietin inactivation develops in the incubation mixtures, and this inactivation appears to be dependent on an enzymatic component in preparations of the factor and on ions in serum.