Hu-1: Major Histocompatibility Locus in Man

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Science  16 Jun 1967:
Vol. 156, Issue 3781, pp. 1506-1508
DOI: 10.1126/science.156.3781.1506


A single locus with 15 or more alleles controls reactivity in mixed leukocyte culture tests. Genes at this locus also control most of the specificities measured by cytotoxic antiserums to leukocytes. Both of these tests can be used to predict survival of skin grafts. It is proposed that this is the major histocompatibility locus in man.