Ionic Mechanism of Cholinergic inhibition in Molluscan Neurons

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Science  23 Jun 1967:
Vol. 156, Issue 3782, pp. 1595-1596
DOI: 10.1126/science.156.3782.1595


Acetylcholine, the inhibitory transmitter to the so-called H-neurons of molluscs, produces its effect by increasing the permeability of the subsynaptic membrane to chloride ions. The change in permeability gives rise to a net influx of this anion, which hyperpolarizes the neuron. The presence of an outward pump of chloride ions is postulated to account for the required electrochemical gradient. The participation of potassium ions in this inhibitory phenomenon was not detected.