Ionic Mechanisms of Cholinergic Excitation in Molluscan Neurons

Science  23 Jun 1967:
Vol. 156, Issue 3782, pp. 1597-1599
DOI: 10.1126/science.156.3782.1597


Acetylcholine appears to be an excitatory transmitter at synapses on two different types of molluscan nerve cells: the so-called D- and CILDA neurons. The action of this substance is different in the two cases. In D-neurons, this compound increases the permeability of the subsynaptic or somatic membrane to chloride ions, and through a net efflux of this anion, depolarizes the cell. In CILDA neurons, on the other hand, acetylcholine depolarzies the cell by increasing its permeability to sodium ions.