Carboxy-Terminal Amino Acids of γA and γM Heavy Chains

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Science  23 Jun 1967:
Vol. 156, Issue 3782, pp. 1609-1610
DOI: 10.1126/science.156.3782.1609


The carboxy-terminal amino acids of α-and µ-chains from human immunoglobulins and α-chains from mouse immunoglobulins have been determined by carboxypeptidase digestion and hydrazinolysis. The data suggest the following carboxy-terminal sequences: human µ: Ala-Gly-Thr-Cys-TyrCOOH; human α: Thr-Cys-TyrCOOH; murine α: (Ileu, Cys)-TyrCOOH.