Nerve Regeneration: Correlation of Electrical, Histological, and Behavioral Events

Science  23 Jun 1967:
Vol. 156, Issue 3782, pp. 1640-1643
DOI: 10.1126/science.156.3782.1640


Wihtin 5 days after the leg nerves of a cockroach are injured, miniature end-plate potentials have disappeared. and the muscle is unresponsive to electrical stimulation. The soma of the injured neutron has a dense perinuclear ring of RNA. By 40 days after the injury, locomotor activity has returned, and the miniature end-plate potentials and evoked electrical responses have reappeared in the muscle. The RNA ring has disappeared, and the nucleus of the regenerating neuron has shifted to an eccentric position.