Hereditary Renal Disease in a Mutant Strain of Rats

Science  30 Jun 1967:
Vol. 156, Issue 3783, pp. 1742-1744
DOI: 10.1126/science.156.3783.1742


Disease of the kidney developed in breeding stock of Gunn rats. The renal lesion is the result of a new mutation. The genetic defect is inherited as an autosomal dominant trait and is apparently lethal in the homozygous condition. The abnormality manifests itself as a congenital hydronephrosis with related cystic changes in the kidney.