Adenyl Cyclase Activity in Rat Pineal Gland: Effects of Chronic Denervation and Norepinephrine

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Science  30 Jun 1967:
Vol. 156, Issue 3783, pp. 1750-1752
DOI: 10.1126/science.156.3783.1750


Adenyl cyclase activity in the pineal gland of rats was determined by measuring the rate of formation of radioactive cyclic 3',5'-adenosine monophosphate from 14C-labeled adenosine triphosphate. Norepinephrine added in vitro to pineal homogenates enhanced this activity, while denervation of the pineal gland by superior cervical ganglionectomy did not significantly reduce it. The enzyme in these denervated glands was more responsive to the stimulatory effects of norepinephrine.