Regulation of the Adrenal Cortex Secretory Pattern by Adrenocorticotropin

Science  30 Jun 1967:
Vol. 156, Issue 3783, pp. 1753-1755
DOI: 10.1126/science.156.3783.1753


Adrenal gland homogenates from rabbits stimulated for 28 days with adrenocorticotropin have been shown to synthesize cortisol. The total amount of cortisol formed was the same whether progesterone-4-14C or Δ5-pregnenolone-4-14C was used as exogenous substrate. However, when Δ5-pregnenolone substrate was used the specific activity of the isolated cortisol was four times as great as when progesterone was used.