Adenovirus Endocarditis in Mice

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Science  07 Jul 1967:
Vol. 157, Issue 3784, pp. 69-70
DOI: 10.1126/science.157.3784.69


Viral endocarditis developed in 24 percent of 50 newborn mice 6 to 8 days after intraperitoneal inoculation with murine adenovirus. Typical adenovirus intranuclear inclusions were seen in heart-valve lesions, and high titers of virus were recovered from heart tissue. Furthermore, adenovirions were directly visualized by electron microscopy within endothelial cells and fibroblasts of the heart valves.