Structural Basis for the Inhibition of Protein Biosynthesis: Mode of Action of Tubulosine

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Science  07 Jul 1967:
Vol. 157, Issue 3784, pp. 84-85
DOI: 10.1126/science.157.3784.84


A structural model for the inhibition of protein biosynthesis was previously formulated on the basis of a topochemical analogy between the ipecac alkaloids and the glutarimide antibiotics. The structure of tubulosine satisfies the requirements of this model. The prediction that such a compound would exhibit amebicidal activity and act by selectively inhibiting the transfer reaction in protein biosynthesis is confirmed.