Inhibition of Banana Polyphenoloxidase by 2-Mercaptobenzothiazole

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Science  14 Jul 1967:
Vol. 157, Issue 3785, pp. 200-201
DOI: 10.1126/science.157.3785.200


2-Mercaptobenzothiazole is an exceptionally potent inhibitor of banana polyphenoloxidase; it significantly delays the onset of substrate oxidation at concentrations as low as 10-7M and causes prolonged inhibition at 2 x 10-5M or higher. Inhibition results from formation of a dissociable, mixed complex between the enzyme and the inhibitor.