Antibody Variability

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Science  21 Jul 1967:
Vol. 157, Issue 3786, pp. 267-273
DOI: 10.1126/science.157.3786.267


I have analyzed the available amino acid sequence data from 30 myelomatosis-derived proteins. Several types of variation are apparent. I conclude that a major and genetically predetermined contribution to the variability of these proteins and of antibodies could be provided by chromosomal rearrangements resulting from somatic recombination between similar but not identical genes in antibody gene pairs. My hypothesis suggests many new types of experiment and can be tested (31).