Release of Slow-Reacting Substance of Anaphylaxis in the Rat: Polymorphonuclear Leukocyte

Science  21 Jul 1967:
Vol. 157, Issue 3786, pp. 318-319
DOI: 10.1126/science.157.3786.318


The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.