Genetic Recombination in Escherichia coli: Clone Heterogeneity and the Kinetics of Segregation

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Science  21 Jul 1967:
Vol. 157, Issue 3786, pp. 319-321
DOI: 10.1126/science.157.3786.319


Several recombinant types may be produced from a single Escherichia coli zygote when the donor parent is Hfr-Hayes and segregation is delayed; usually only one type is produced with Hfr-Cavalli. Statistical experiments confirm well-known pedigree analyses by micromanipulation and suggest that DNA synthesis is required before final genetic integration.