Amnesic Effects of Small Bilateral Brain Puncture in the Mouse

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Science  21 Jul 1967:
Vol. 157, Issue 3786, pp. 334-336
DOI: 10.1126/science.157.3786.334


A small acute brain puncture produced retrograde amnesia in a passive avoidance learning situation in mice. If injury to the hippocampus was inflicted either immediately, 1 hour after the learning, or 1 hour before the learning, the animals showed a retention deficit; the degree of this deficit was related to the time interval. No effect of this injury was observed on retest performance when the animals were treated as long as 6 hours before or after the learning trial.