Deficient Complement Fixation by Aggregated Gamma Globulin from Hypogammaglobulinemic Patients

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Science  28 Jul 1967:
Vol. 157, Issue 3787, pp. 454-455
DOI: 10.1126/science.157.3787.454


We found that several normal samples of aggregated gamma globulin consistently fixed essentially equal amounts of guinea pig complement, while samples of gamma globulin from three of four hypogammaglobulinemic patients were markedly deficient in this biologic function. Thus, the previously observed limited heterogeneity of gamma globulin in patients with hypogammaglobulinemia is also associated with inefficiency in at least one biological function.