Polydipsia Elicited by the Synergistic Action of a Saccharin and Glucose Solution

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Science  04 Aug 1967:
Vol. 157, Issue 3788, pp. 552-554
DOI: 10.1126/science.157.3788.552


Rats consume significantly more of a solution combining saccharin and glucose than equivalent solutions of these substances presented in separate bottles. Fluid consumption may exceed body weight. Experiments helping to delineate the basis of this synergistic action are presented.