Deoxycytidylate and Deoxyguanylate Kinase Activity in Pneumococci after Exposure to Known Polyribonucleotides

See allHide authors and affiliations

Science  18 Aug 1967:
Vol. 157, Issue 3790, pp. 821-822
DOI: 10.1126/science.157.3790.821


Polycytidylic acid and to a lesser extent polyadenylic acid enhance the activity of deoxycytidylate and deoxyguanylate kinases in resting cell suspensions of encapsulated pneumococci. The active intracellular materials appear to be oligomers of A and C, respectively. The stimulation of the kinase activities is amino-acid dependent and can be abolished by the addition of chloramphenicol. The addition of all eight naturally occurring deoxyribonucleosides and deoxyribonucleotides to cell suspensions containing the homopolymers leads to a selective enhancement of DNA synthesis.