Collagen Proline Hydroxylase in Wound Healing, Granuloma Formation, Scurvy, and Growth

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Science  25 Aug 1967:
Vol. 157, Issue 3791, pp. 927-929
DOI: 10.1126/science.157.3791.927


Compared to homologous tissues from adult animals, rapidly growing embryonic and fetal tissues contain large amounts of collagen proline hydroxylase. Lung and skin from scorbutic guinea pigs contain one-third as much enzyme as normal tissues do. A rapid increase in proline hydroxylase occurs on the 2nd day of formation of granuloma after injection of carrageenan and on the 4th day of wound healing. The increase in enzyme activity is associated with the onset of collagen biosynthesis and deposition.