Immunoglobulin A: Localization in Rectal Mucosal Epithelial Cells

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Science  25 Aug 1967:
Vol. 157, Issue 3791, pp. 930-931
DOI: 10.1126/science.157.3791.930


Immunofluorescence studies with monospecific antiserums to human serum immunoglobulins consistently revealed immunoglobulin A within the apical portion of the cytoplasm of rectal mucosal epithelial cells in normal subjects, as well as in patients with various bowel diseases. Immunoglobulins M, G, and D were not demonstrated within mucosal epithelial cells. The predominance of lymphoid cells containing immunoglobulin A in the lamina propria of intestinal tissues was confirmed.