Distribution of Circulation Rates within a Single Tissue Type

See allHide authors and affiliations

Science  25 Aug 1967:
Vol. 157, Issue 3791, pp. 942-943
DOI: 10.1126/science.157.3791.942


An analysis is undertaken to determine the continuous distribution of circulation rates which would be necessary for a single tissue type to display a simple exponential response for the exchange of a solute with blood. It is shown that there can be no more than one real solution. This indicates that heterogeneous circulation cannot be invoked to explain anomalies to the popular assumption that blood perfusion is the process limiting the rate of blood-tissue exchange.