Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

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Science  01 Sep 1967:
Vol. 157, Issue 3792, pp. 1060-1062
DOI: 10.1126/science.157.3792.1060


Lymph node cells from inbred rats having delayed sensitivity to soluble proteins inhibit growth of syngeneic or allogeneic fibroblasts in the presence of specific antigen. A relation is suggested between this in vitro phenomenon and other systems believed to be specific manifestations of delayed hypersensitivity.