Orientation of Nonsense Codons on the Genetic Map of the Lac Operon

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Science  08 Sep 1967:
Vol. 157, Issue 3793, pp. 1176-1177
DOI: 10.1126/science.157.3793.1176


Intracodon recombination is used to orient the nonsense codons UGA, UAG, and UAA on the genetic map of the (lactose) lac operon of Escherichia coli. The 5'-end of these triplets is toward the operator end of the operon. A hypothesis is presented to explain the fact that the frequency of recombination between adjacent nucleotides is many times lower than expected.