Prostaglandins: Localization in Subcellular Particles of Rat Cerebral Cortex

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Science  08 Sep 1967:
Vol. 157, Issue 3793, pp. 1187-1189
DOI: 10.1126/science.157.3793.1187


Homogenates of rat cerebral cortex contain material corresponding to prostaglandins E1, E2, F1α, and F2α which are concentrated mainly in the light microsomal and mitochondrial fractions. Only the former fraction exhibits significant ability to synthesize prostaglandins E1 and F1α from bis-homo-γ-linolenic acid. After subfractionation of the crude mitochondrial fraction, prostaglandin E and F material is found mainly in the cholinergic and noncholinergic nerve endings. We conclude that the nerve endings are a storage site, whereas the light microsomes are the site of synthesis.