Hydroxyethyl Starch: Extracellular Cryophylactic Agent for Erythrocytes

Science  15 Sep 1967:
Vol. 157, Issue 3794, pp. 1312-1313
DOI: 10.1126/science.157.3794.1312


Studies in vitro indicate that hydroxyethyl starch is an effective extracellular cryoprotective agent for erythrocytes. It is as effective as polyvinylpyrrolidone in cryophylactic ability. It is degraded to glucose units in the circulation, is not retained in tissues, and is inexpensive to produce. Changes in the size and degree of hydroxyethylation of the branched-chain starch may result in a more effective cryoprotective agent.